Supplementary Figure 6: Neutralization of TNF in mice with chronic neonatal LCMV strain WE infection restores cytokine production by CD4+ and CD8+ T cells. | Nature Immunology

Supplementary Figure 6: Neutralization of TNF in mice with chronic neonatal LCMV strain WE infection restores cytokine production by CD4+ and CD8+ T cells.

From: Tumor-necrosis factor impairs CD4+ T cell–mediated immunological control in chronic viral infection

Supplementary Figure 6

(a) Numbers of IL-2 and (b) IFN-γ expressing splenic gp33+CD8+ T cells after TNF neutralization in cnLCMV-WE mice. Numbers of (c) IL-2, (d) IFN-γ, (e) IL-21, and (f) CD40L expressing splenic gp66+CD4+ T cells. (g) Cumulative flow cytometric analysis of TNF expression in splenic gp66+CD4+ T cells. (h) Numbers of TNF expressing splenic gp66+CD4+ T cells. (a-f,h) *P < 0.05 (Student’s t-test). (a-h) Mean ± s.e.m. Each n = 5. Data are representative of two independent experiments. n.s. not significant.

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