Supplementary Figure 8: Suppression of effector differentiation by pharmacological inhibition of Akt is partially dependent on BACH2.
From: BACH2 regulates CD8+ T cell differentiation by controlling access of AP-1 factors to enhancers
a-b, Naïve CD44− CD62L+ WT and KO CD8+ T cells (a) were stimulated in the presence of 100IU rhIL-2 in the presence or absence of 1μM AKTi. Expression of IFN-γ and TNF was measured 4 days after stimulation by intracellular cytokine staining. Numbers in gates indicate percentages. Bars and error represent mean and s.e.m. ***P<0.005; ****P<0.001. Data (a-b) are representative of 2 independently repeated experiments.
