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PP2A's restraint of mTOR is critical for Treg cell activity

Nature Immunology volume 17, pages 478–479 (2016)Cite this article

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Regulatory T cells must limit activation of the metabolic checkpoint kinase mTOR to maintain their identity. The lipid ceramide serves a unique role in this process by inducing phosphatase PP2A–mediated inhibition of the mTORC1 complex.

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Figure 1: Inhibiting inhibitors: how Foxp3 limits mTORC1 signaling.

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  1. and the Department of Immunology, Greg M. Delgoffe is in the Tumor Microenvironment Center, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.,

    Greg M Delgoffe

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  1. Greg M Delgoffe
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Correspondence to Greg M Delgoffe.

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Delgoffe, G. PP2A's restraint of mTOR is critical for Treg cell activity. Nat Immunol 17, 478–479 (2016). https://doi.org/10.1038/ni.3442

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