Supplementary Figure 6: Mevalonate pathway controls innate immune response through protein geranylgeranylation.
From: Control of the innate immune response by the mevalonate pathway
The mevalonate pathway provides geranylgeranyl pyrophosphate for protein geranylgeranylation. Protein geranylgeranylation regulates TLR-induced PI(3)Kinases activation through geranylgeranylation of Kras. PI(3)Ks and its downstream kinases in turn control the expression of pro- and anti-inflammatory cytokine genes and the Pyrin-encoding Mefv gene in macrophages.
