Supplementary Figure 1: Enhanced proinflammatory cytokine production and inhibited IL-10, MIP1α, MIP1α β, MCP-1 and Rantes in Pggt1b-deficient macrophages. | Nature Immunology

Supplementary Figure 1: Enhanced proinflammatory cytokine production and inhibited IL-10, MIP1α, MIP1α β, MCP-1 and Rantes in Pggt1b-deficient macrophages.

From: Control of the innate immune response by the mevalonate pathway

Supplementary Figure 1

(a) Quantitative RT-PCR analysis of transcript abundance of Il1a, Il1b, TNF, Il6, Il18, Il12a, Ifnb1 and Il10 in Pggt1b+/+ Lyz2-Cre and Pggt1b fl/flLyz2-Cre macrophages stimulated with LPS (200ng/ml) for 0, 2, 4 or 16 hours; (b) Multiplex assay of cytokine production in Pggt1b+/+ Lyz2-Cre and Pggt1b fl/flLyz2-Cre macrophages stimulated with LPS (200ng/ml) for 0, 4 and 24 hours. (*P<0.05, **P<0.001, ***P<0.0001, Two Way ANOVA)

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