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The Itch to degrade ROR-γt

Nature Immunology volume 17, pages 898–900 (2016)Cite this article

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The E3 ubiquitin ligase Itch limits interleukin 17A (IL-17A)-mediated intestinal inflammation by targeting the transcription factor ROR-γt for proteasomal degradation.

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Figure 1: Itch limits the production of IL-17A by TH17 cells, γδ T cells and group 3 innate lymphoid cells by targeting ROR-γt for proteasomal degradation.

Marina Corral Spence/Nature Publishing Group

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Authors and Affiliations

  1. Sascha Rutz is in the Department of Cancer Immunology, Genentech, South San Francisco, California, USA.,

    Sascha Rutz

  2. Wenjun Ouyang is in the Department of Inflammation and Oncology, Amgen, South San Francisco, California, USA.,

    Wenjun Ouyang

Authors
  1. Sascha Rutz
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  2. Wenjun Ouyang
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Corresponding authors

Correspondence to Sascha Rutz or Wenjun Ouyang.

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Competing interests

S.R. is an employee of Genentech, and W.O. is an employee of Amgen.

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Rutz, S., Ouyang, W. The Itch to degrade ROR-γt. Nat Immunol 17, 898–900 (2016). https://doi.org/10.1038/ni.3516

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