Supplementary Figure 8: PKA C-α and NLRP3 interact.
From: NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations
(a) Flow of NLRP3 ATPase assay used in Figure 6e and Figure 7e. (b,c) Immunoprecipitation of indicated protein of BMDMs primed for 3.5 h with LPS and treated for 5 min with forskolin (50 μM) in the presence or absence of PKI (1 μM). (b,c) Data are from one experiment representative of three separate experiments with similar results, (b,c) BMDM were derived from 2 mice per experiment mixed together.
