Supplementary Figure 7: Proposed pathway.
From: Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype
(a) Schematic representation of the suggested pathway of how glioma cells induce microglial caspase-3 S-nitrosylation, decreasing caspase-3 proteolytic activity and promoting their conversion towards a tumor-supporting activation state. (b) Illustration of how caspase-3 like (DEVDase) activity based on its degree of activation will regulate different microglial activation states (tumor-supporting versus pro-inflammatory phenotypes), or in some circumstances with very high activity levels, even cell death.
