Supplementary Figure 4: Ablation of Il6 in B cells, T cells or macrophages does not result in resistance to MOG(35–55)-induced EAE. | Nature Immunology

Supplementary Figure 4: Ablation of Il6 in B cells, T cells or macrophages does not result in resistance to MOG(35–55)-induced EAE.

From: Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells

Supplementary Figure 4

Course of MOG(35-55) induced EAE in mouse strains with conditional ablation of Il6 in B cells (CD19-Cre x Il6flox/flox, Il6ΔB) (a), T cells (CD4-Cre x Il6flox/flox, Il6ΔT) (b), and LysM+ myeloid cells (LysM-Cre x Il6flox/flox, Il6ΔM Φ) (c). Mice were subcutaneously immunized with MOG(35-55) in CFA and i.v. injected with pertussis toxin on days 0 and 2. Mean clinical EAE score and SEM, n ≥ 4 per group. *P<0.05, ANOVA plus Fisher's LSD test for individual days.

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