Supplementary Figure 8: IL-6 trans-signaling by the soluble IL-6–IL-6Rα complex is irrelevant during MOG(35–55)-induced EAE.
From: Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells
WT mice, opt_sgp130-Fc transgenic mice, and Il6-/- mice were immunized with MOG(35-55) in CFA. Opt_sgp130-Fc transgenic mice produce large amounts of sgp130, which blocks endogenous IL-6 trans-signaling in vivo. Mean EAE scores + SEM, *P<0.04, ANOVA plus Tukey post test.
