Supplementary Figure 10: IL-6 cluster signaling is sufficient to induce pathogenic TH17 cells in the simultaneous absence of classic IL-6 signaling and the IL-21-mediated alternative pathway for the induction of TH17 cells. | Nature Immunology

Supplementary Figure 10: IL-6 cluster signaling is sufficient to induce pathogenic TH17 cells in the simultaneous absence of classic IL-6 signaling and the IL-21-mediated alternative pathway for the induction of TH17 cells.

From: Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells

Supplementary Figure 10

Naive CD4+ T cells were purified from Il6raflox/flox control mice, Il6raΔT mice, Il21r-/- mice, or Il6raΔT x Il21r-/- mice and transferred into Rag1-/- host animals followed by immunization with MOG(35-55) in CFA. (a) Intracellular cytokine staining of T cells re-isolated from the spleen on day 14 after immunization and subjected to ex vivo stimulation with PMA/ionomycin. (b) Clinical course of EAE in Rag1-/- recipients of T cells deficient in both IL-6Rα and IL-21R. Mean clinical score + SEM, n=3.

Back to article page