Supplementary Figure 3: Female-biased genes and autoimmune diseases. | Nature Immunology

Supplementary Figure 3: Female-biased genes and autoimmune diseases.

From: A gene network regulated by the transcription factor VGLL3 as a promoter of sex-biased autoimmune diseases

Supplementary Figure 3

a, top functions enriched in female-biased genes. b, SLE/Systemic sclerosis and the atopic dermatitis loci are enriched with female-bias genes. c, the null distribution for the expected overlap for random loci, with red lines illustrating the observed overlap results from the SLE/SS (top) and AD (bottom), respectively. d, qRT-PCR analyses of female-biased immune genes in T cells extracted from blood of healthy humans (n=9 each sex). F, female. M, male. Mean ± s.e.m, * P<0.05. Student’s t-test. e-i, scatter plot of gene expression levels from RNA-Seq of human skin biopsies versus age at biopsy for ITGAM, C3, CFB, DOCK2, and FCER1G.

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