Supplementary Figure 5: Characterization of regions with H3K27me3 peaks in control and UTX-KO iNKT cells. | Nature Immunology

Supplementary Figure 5: Characterization of regions with H3K27me3 peaks in control and UTX-KO iNKT cells.

From: The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells

Supplementary Figure 5

(a) GREAT analysis of WT-specific H3K27me3 peaks (n = 4,250). (b) GREAT analysis of UTX KO-specific H3K27me3 peaks (n = 9,645). (c,d) Assessing statistical significance of H3K27me3 distribution around the promoters of downregulated (c) and upregulated (d) genes between WT and UTX-deficient (KO) iNKT cells based on permutation test where 100,000 permutations were used to calculate the distribution of the difference between two average profiles. Black line depicts empirical null model, dotted red line indicates the observed value for the measured profiles. (e,f) GREAT analysis of all downregulated (e) or upregulated (f) genes in UTX KO iNKT cells compared to WT controls.

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