Supplementary Figure 8: Characterization of iNKT cell super-enhancers. | Nature Immunology

Supplementary Figure 8: Characterization of iNKT cell super-enhancers.

From: The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells

Supplementary Figure 8

(a,b) Epigenetic landscape of the super-enhancers for Tbx21 (a) and Il2rb (b) that exhibit UTX-dependent accessibility. Depicted are the ChIP-Seq tracks of H3K27ac and heat maps of ATAC-Seq, H3K27me3, and H3K4me3 in WT or UTX-deficient (KO) iNKT cells around the super-enhancer (SE) for Tbx21 (a) and Il2rb (b). Zoomed in tracks in Fig. 8f and Fig. 8g are shown in black rectangle and highlighted with a star. (c) GREAT analysis of the super-enhancer elements in iNKT cells. (d) GREAT analysis of the SE elements in iNKT cells that exhibit UTX-dependent accessibility. (e) Transcription factor target motif analysis using Haystack in iNKT cell SE elements that exhibit UTX-dependent accessibility. Depicted are the binding motifs of RELA and BHLHE40.

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