Supplementary Figure 3: Establishment of individual SEs in developing tTreg cells.
From: Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment
(a-c) Changes in various epigenetic modifications, mRNA transcription and transcription factor binding during Treg cell development around representative Treg-SE regions at the Ctla4, Il2ra and Ikzf2 loci (a), common-SE region at the Ets1 locus (b) and Tconv-SE region at the Tcf7 locus (c). H3K27ac, H3K4me1, H3K27me3, ATAC-seq, MBD-seq and RNA-seq signals in DP, immature CD4SP (imCD4SP), tTreg precursor (pre-tTreg), thymic Treg (thyTreg) and peripheral Treg cells, binding of various transcription factors in DP and Treg cells, and vertebrate conservation score are shown. Bars indicate 25 kb. Data are from one experiment (ATAC-seq, H3K4me1 and H3K27me3 ChIP-seq), representative of two independent experiments (H3K27ac ChIP-seq, H3K4me3 ChIP-seq and MBD-seq), or average of two independent experiments (RNA-seq).
