Supplementary Figure 1: Phenotypic evaluation of Tsc2fl/fl,Lyz2-Cre mice. | Nature Immunology

Supplementary Figure 1: Phenotypic evaluation of Tsc2fl/fl,Lyz2-Cre mice.

From: Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression

Supplementary Figure 1

(a) Mac-2 and p-S6 immunofluorescence of liver sections of 3 month-old Tsc2fl/fl and Tsc2fl/fl,Lyz2-Cre mice. Scale bar, 100 μm. (b) Lung section of a 3 month-old Tsc2fl/fl,Lyz2-Cre mouse evaluated by H&E staining. Scale bar, 50 μm. (c) Mediastinal and superficial cervical lymph nodes (LN) of 3 month-old mice were evaluated by H&E staining or by immunohistochemistry with Mac-2. Black scale bar, 200 μm, white scale bar 25 μm. (d) Lung sections of Tsc2fl/fl and Tsc2fl/fl,Lyz2-Cre mice were stained with immunohistochemistry for myeloperoxidase (MPO). Scale bar, 25 μm. Data are representative of three mice (a,c,d) or five mice (b) per genotype.

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