Supplementary Figure 2: Postprandial macrophage-derived IL-1β promotes insulin secretion. | Nature Immunology

Supplementary Figure 2: Postprandial macrophage-derived IL-1β promotes insulin secretion.

From: Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation

Supplementary Figure 2

(a) Blood glucose levels before (fasted) or after refeeding (refed) in WT and Il1b–/– littermate mice (n=12 and 6, respectively). (b) Representative FACS plot of peritoneal macrophage (CD11b+, F4/80+) depletion in WT mice 3 days after injection of 10 ml/kg clodronate or PBS liposomes, gated on live single cells. (c) Blood glucose levels following acute injections of saline or 10 mg/kg IL-1Ra in refed WT mice (n=26 and 23, respectively). *P<0.05, **P < 0.01. Statistical significance (P) was determined by Student's t test and in (a) by ANOVA. All error bars denote s.e.m.

Back to article page