Supplementary Figure 5: MSC participates in epigenetic modification of the TH2 locus in iTreg cells. | Nature Immunology

Supplementary Figure 5: MSC participates in epigenetic modification of the TH2 locus in iTreg cells.

From: The transcription factor musculin promotes the unidirectional development of peripheral Treg cells by suppressing the TH2 transcriptional program

Supplementary Figure 5

ChIP-PCR analysis of the binding of AcH4 (a), H3K9Ac (b), H3K4me3 (c) and H3K27me3 (d) on the indicated sites on TH2 and Foxp3 locus in the WT or Msc–/– naïve T cells stimulated with TGF-β for 12 and 48 hours. Data representative of three independent experiments. *P < 0.05, **P < 0.01, (Student's t-test, error bars, SD).

Back to article page