Supplementary Figure 4: Dynamics of the gd TCR repertoire in alloHSCT patients without and with reactivation of CMV. | Nature Immunology

Supplementary Figure 4: Dynamics of the gd TCR repertoire in alloHSCT patients without and with reactivation of CMV.

From: Human γδ T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection

Supplementary Figure 4

(a,b) Stacked area graphs illustrate proportions of Top20 clones before and after alloHSCT in (a) four patients without and (b) four patients with CMV reactivation, while all other non-Top20 clones are summarized in light grey (related to Fig. 4a,b and 5a,b of the main manuscript). Expanded Top20 Vγ9+ and Vδ2+ sequences are highlighted in blue colors, Vγ9− and Vδ2− sequences are highlighted in orange colors. The day of transplantation (Tx) was set to zero to reflect T cell depletion, but no blood was drawn at Tx. Sequences appearing in the Top20 before, but not after Tx, are coded in gray shades. Arrows in (b) indicate the day of CMV-reactivation. Indicated pre-transplant repertoires could not be determined (nd) due to sample quality.

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