Supplementary Figure 6: Treatment with anti-TNF and anti-IL6R reverses dysbiosis in Nlrp12–/– mice. | Nature Immunology

Supplementary Figure 6: Treatment with anti-TNF and anti-IL6R reverses dysbiosis in Nlrp12–/– mice.

From: NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth

Supplementary Figure 6

(a, b) Flow chart showing WT and Nlrp12–/– littermates treated with anti-TNF and anti-IL6R antibodies (Ab) or PBS, and experimental strategy for Ab dosing (filled triangles) and fecal collection (open triangles) (n=6 mice/group). (c) Microbial diversity and (d) PCoA plots of microbial compositional differences in WT and Nlrp12–/– mice before antibody treatment. (e) Quantification of UniFrac distances calculated from (d) represented as dissimilarity values. Error bars show SEM. *p<0.05, **p<0.01, ****p<0.0001 and n.s. means no significance determined by two-tailed unpaired t test (c) or ANOSIM (e).

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