Supplementary Figure 1: NLRP12 is downregulated in biopsy samples from patients with active ulcerative colitis (UC). | Nature Immunology

Supplementary Figure 1: NLRP12 is downregulated in biopsy samples from patients with active ulcerative colitis (UC).

From: NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth

Supplementary Figure 1

(a-g) NLRP12 expression in 7 UC mRNA profiling studies deposited in NCBI GEO database. Disease stages, GEO accession numbers, subject tissues for mRNA purification, therapeutic treatments including corticosteroid or anti-TNF (infliximab) and mRNA measuring microarrays and sequencer platforms are listed. For (a), n=5/group; (b), healthy (n=6), UC nonresponse (n=13), UC response (n=8); (c) healthy (n=20), active UC (n=15), inactive UC (n=18); (d) healthy (n=12), active UC (n=13); (e) n=20/group; (f) healthy (n=6), UC before treatment (n=20), UC response to treatment (n=8); (g) healthy (n=42), UC (n=40). Error bars show SEM. *p<0.05, **p<0.01 and n.s. means no significance determined by two-tailed unpaired t test.

Back to article page