Supplementary Figure 7: Differential protein secretion patterns and intracellular signaling networks.
From: Social network architecture of human immune cells unveiled by quantitative proteomics
(a, b) Volcano plots of secreted proteins from mDCs (a) and pDCs (b). Significantly secreted proteins are colored in blue (FDR 0.05, S0=1, n=4 from independent donors). Known cytokines are labelled in green.
(c) Intracellular signaling adaptors and transcription factors (columns) for each cell type (rows) that propagate intercellular signals upon receptor ligation by proteins secreted by mDCs and pDCs.
(d, e) Volcano plots of secreted proteins from classical monocytes activated with lipopolysaccharide (LPS) (d) or zymosan (ZYM) (e). Significantly secreted proteins are colored in blue (FDR 0.01, S0=1, n=5 from independent donors). Known cytokines are labelled in green.
(f) Intracellular signaling adaptors and transcription factors (columns) for each cell type (rows) that propagate intercellular signals upon receptor ligation by proteins secreted by cMO.
