Supplementary Figure 8: Bhlhe41 and Bhlhe40 regulate expression of the receptors for IL-5 and IL-3. | Nature Immunology

Supplementary Figure 8: Bhlhe41 and Bhlhe40 regulate expression of the receptors for IL-5 and IL-3.

From: Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells

Supplementary Figure 8

(a) Expression of the Tnfrsf13b (TACI) and Tnfrsf13c (BAFF-R) genes in VH12/Vκ4 transgenic (top) and polyclonal (bottom) wild-type and DKO B-1a cells, as determined by two independent RNA-seq experiments per cell type. Error bars indicate s.e.m. TPM, transcripts per million. (b) Surface IL-5Rα and IL-3Rα expression on polyclonal B-1a cells of the indicated genotypes (top) as well as surface IL-5Rα expression on VH12/Vκ4 transgenic B-1a cells (bottom left) and B-1a cells from mixed fetal liver (FL) chimeras (bottom right). One representative result of at least two independent experiments is shown.

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