Supplementary Figure 2: Absence of immune infiltration and neurodegenerative signs in Nrros−/− mice. | Nature Immunology

Supplementary Figure 2: Absence of immune infiltration and neurodegenerative signs in Nrros−/− mice.

From: Mice deficient in NRROS show abnormal microglial development and neurological disorders

Supplementary Figure 2

Representative images of spinal cord cross sections from Nrros+/+ and Nrros-/- animals stained with (a) H&E (bar = 50 μm), (d) Nissl (bar = 500 μm) or (e) Luxol fast blue (bar = 1 mm). (b) Survival curve (n = 10) and (c) wire hang from WT and Nrros-/-Rag2-/- animals (12 - 14 weeks old; n = 5). Quantification of (f) number of axons per area, (g) total number of axons and (h) percent axons with indicated lumen area from p-Phenylenediamine staining on cross sections of sciatic nerve (n = 8). 15-week old Nrros+/+ and Nrros-/-animals are shown. Error bar: ± SEM. ***P < 0.001. Log rank test (b), One-way ANOVA (c), unpaired Student’s t-test (f - h).

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