Supplementary Figure 5: Loss of NOX2 fails to rescue neurological phenotype in Nrros−/− mice.
From: Mice deficient in NRROS show abnormal microglial development and neurological disorders
(a) mRNA expression of Cybb (NOX2) in Nrros+/+ and Nrros-/- brains from RNA-seq. (b - f) Performance of Nrros+/+, Nrros-/-, Cybb-/- and Nrros-/-Cybb-/- in rotarod test at (b) pretraining (9 weeks), (c) fixed and (d) accelerating conditions. S, session; T, trial. (e) Total beam breaks and (f) percent center beam breaks in open field test. Animals were 11-week old unless specified otherwise (n = 16). Error bar: ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001. One-way ANOVA, (c, e, f); Unpaired Student’s t-test (a - c).
