Supplementary Figure 1: miRNA expression profiling.
From: The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection
MiRNA expression profiling of thymocytes (Thy), total T cells, naïve CD8+ T cells and activated CD8+ T cells (24 and 96 hours post stimulation with CD3+ CD28 antibodies). Also included is an analysis of total B cells, bone marrow-derived DC (DC), lipopolysaccharide activated DC (DC-LPS), kidney and liver. Data represent expression relative to the mean value for each row. (a) Pairwise complete linkage hierarchical clustering of all miRNAs expressed at >3 standard deviations over background in at least one of the samples. (b, c) Expression patterns of miRNAs that are upregulated (b) or downregulated (c) at least 2-fold in CD3+CD28 Ab activated CD8+ T cells compared to naive CD8+ T cells (comparison of days 0, 1 and 4). Data are representative of one experiment.
