Supplementary Figure 5: Increased IL-21 protein in the supernatant from co-culture of OT-II CD4+ T cells and Blimp-1-deficient DCs. | Nature Immunology

Supplementary Figure 5: Increased IL-21 protein in the supernatant from co-culture of OT-II CD4+ T cells and Blimp-1-deficient DCs.

From: Increased cathepsin S in Prdm1−/− dendritic cells alters the TFH cell repertoire and contributes to lupus

Supplementary Figure 5

CD4+ T cells from OT-II mice and splenic DCs (open box is wild-type mice and gray box is CKO mice) were co-cultured in various conditions for 4 days. To measure the secreted cytokines, IL-2 and IL-21, supernatant was collected and cytokines were detected by a multiplex assay. In the box-and-whisker plot, horizontal bars indicate the median, boxes indicate 25th to 75th percentile, and whiskers indicate 10th and 90th percentile (n=6).

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