Supplementary Figure 3: Infection with MuHV-4 induces a long-term protection against HDM-induced airway allergy. | Nature Immunology

Supplementary Figure 3: Infection with MuHV-4 induces a long-term protection against HDM-induced airway allergy.

From: A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes

Supplementary Figure 3

(a-d) Quantification of MuHV-4 specific immunoglobulins in sera by ELISA (a), total and differential cell counts of BALF cells (b), histological analysis of lung sections (scale bars, 100 μm) (c), and ELISA measurement of cytokine release by MLN cells following ex vivo restimulation by HDM (d), at euthanasia of mock or MuHV-4-infected BALB/c mice, submitted 7, 30 or 60 days p.i. to the HDM-induced high dose model of asthma. *** p< 0.001, ** p< 0.01 and * p < 0.05 (Two-way ANOVA and Tukey's multiple comparison test). Data are representative of two independent experiments with 5 mice per group (mean ± s.e.m. in a, b, d).

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