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Taking T cells beyond the diffraction limit

Nature Immunology volume 11, pages 51–52 (2010)Cite this article

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Recent advances in microscopy have enabled imaging of cell surface receptors at ever higher resolutions. A report using the latest technology now provides evidence that the T cell antigen receptor and the adaptor Lat are confined to small islands, which cluster together after triggering of the T cell antigen receptor.

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Figure 1: Single-molecule analysis by PALM9 and fluorescence-correlation spectroscopy12.

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Authors and Affiliations

  1. P. Anton van der Merwe is in the Sir William Dunn School of Pathology, University of Oxford, UK.,

    P Anton van der Merwe

  2. Paul D. Dunne and David Klenerman are in the Department of Chemistry, University of Cambridge, Cambridge, UK.,

    Paul D Dunne & David Klenerman

  3. Nuffield Department of Clinical Medicine, Simon J. Davis is in the Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.,

    Simon J Davis

Authors
  1. P Anton van der Merwe
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  2. Paul D Dunne
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  3. David Klenerman
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  4. Simon J Davis
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Correspondence to P Anton van der Merwe.

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van der Merwe, P., Dunne, P., Klenerman, D. et al. Taking T cells beyond the diffraction limit. Nat Immunol 11, 51–52 (2010). https://doi.org/10.1038/ni0110-51

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