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Dual TCR T cells: gaining entry into the periphery

Nature Immunology volume 3, pages 109–110 (2002)Cite this article

T cells bearing two different TCRs can be detrimental because the unselected TCR has the potential to cause autoimmunity. Evidence is now emerging that the unselected TCR may also be beneficial by expanding the TCR repertoire for foreign antigens.

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Figure 1: Different scenarios for dual TCR T cells.

Bob Crimi

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Authors and Affiliations

  1. Department of Immunology, University of Washington School of Medicine, Seattle, 98195, WA, USA

    Marc A. Gavin & Alexander Y. Rudensky

  2. Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, 98195, WA, USA

    Alexander Y. Rudensky

Authors
  1. Marc A. Gavin
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  2. Alexander Y. Rudensky
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Gavin, M., Rudensky, A. Dual TCR T cells: gaining entry into the periphery. Nat Immunol 3, 109–110 (2002). https://doi.org/10.1038/ni0202-109

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