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Tumor viral escape from inhibited T cells

Functionally active inhibitory receptors that impart negative signals have been found recently on T cells. One such inhibitory receptor, CD94-NKG2A, can induce cytolytic anergy in CTLs specific for polyomavirus.

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Figure 1: Negative signaling by CD94-NKG2A on CTLs and genetic susceptibility to polyomavirus infection.

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Welsh, R., Stepp, S., Szomolanyi-Tsuda, E. et al. Tumor viral escape from inhibited T cells. Nat Immunol 3, 112–114 (2002). https://doi.org/10.1038/ni0202-112

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