Maintenance of hematopoietic stem cells depends on a fine-tuned transcriptional network. A detailed study of the nuclear adaptor Ldb1 provides additional clues as to how hematopoietic stem cell homeostasis is controlled.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to the full article PDF.
USD 39.95
Prices may be subject to local taxes which are calculated during checkout
References
Boiani, M. & Schöler, H.R. Nat. Rev. Mol. Cell Biol. 6, 872–884 (2005).
Souroullas, G.P. et al. Cell Stem Cell 4, 180–186 (2009).
Tsai, F.Y. et al. Nature 371, 221–226 (1994).
Semerad, C.L. et al. Proc. Natl. Acad. Sci. USA 106, 1930–1935 (2009).
Li, et al. Nat. Immunol. 12, 129–136 (2011).
Matthews, J.M. & Visvader, J. EMBO Rep. 4, 1132–1137 (2003).
Wadman, I.A. et al. EMBO J. 16, 3145–3157 (1997).
Song, S.H., Hou, C. & Dean, A. Mol. Cell 14, 810–822 (2007).
Soler, E. et al. Genes Dev. 24, 277–289 (2010).
Adolfsson, J. et al. Immunity 15, 659–669 (2001).
Lin, Y.C. et al. Nat. Immunol. 11, 635–643 (2010).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Welinder, E., Murre, C. Ldb1, a new guardian of hematopoietic stem cell maintenance. Nat Immunol 12, 113–114 (2011). https://doi.org/10.1038/ni0211-113
Published:
Issue date:
DOI: https://doi.org/10.1038/ni0211-113
