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Dendritic cells giveth and taketh away

Nature Immunology volume 6, pages 227–228 (2005)Cite this article

Resting dendritic cells can induce T cell tolerance. This process requires engagement of the costimulatory molecules PD-1 and CTLA-4 on T cells.

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Figure 1: Immune activation and tolerance induced by dendritic cells.

K.R.

References

  1. Probst, H.C., Lagnel, J., Kollias, G. & van den Broek, M. Immunity 18, 713–720 (2003).

    Article  CAS  Google Scholar 

  2. Probst, H.C. et al. Nat. Immunol. 6, 280–286 (2005).

    Article  CAS  Google Scholar 

  3. Hawiger, D. et al. J. Exp. Med. 194, 769–779 (2001).

    Article  CAS  Google Scholar 

  4. Steinman, R.M., Hawiger, D. & Nussenzweig, M.C. Annu. Rev. Immunol. 21, 685–711 (2003).

    Article  CAS  Google Scholar 

  5. Moser, M. Immunity 19, 5–8 (2003).

    Article  CAS  Google Scholar 

  6. Schwartz, R.H. Annu. Rev. Immunol. 21, 305–334 (2003).

    Article  CAS  Google Scholar 

  7. Perez, V.L. et al. Immunity 6, 411–417 (1997).

    Article  CAS  Google Scholar 

  8. Greenwald, R.J., Boussiotis, V.A., Lorsbach, R.B., Abbas, A.K. & Sharpe, A.H. Immunity 14, 145–155 (2001).

    Article  CAS  Google Scholar 

  9. Latchman, Y.E. et al. Proc. Natl. Acad. Sci. USA 101, 10691–10696 (2004).

    Article  CAS  Google Scholar 

  10. Bennett, F. et al. J. Immunol. 170, 711–718 (2003).

    Article  CAS  Google Scholar 

  11. Salomon, B. & Bluestone, J.A. Annu. Rev. Immunol. 19, 225–252 (2001).

    Article  CAS  Google Scholar 

  12. Lohr, J., Knoechel, B., Jiang, S., Sharpe, A.H. & Abbas, A.K. Nat. Immunol. 4, 664–669 (2003).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Pathology, University of California San Francisco, San Francisco, 94143, California, USA

    Abul K Abbas & Arlene H Sharpe

  2. Department of Pathology, Harvard Medical School and Brigham & Women's Hospital, Boston, 02115, Massachusetts, USA

    Abul K Abbas & Arlene H Sharpe

Authors
  1. Abul K Abbas
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  2. Arlene H Sharpe
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Abbas, A., Sharpe, A. Dendritic cells giveth and taketh away. Nat Immunol 6, 227–228 (2005). https://doi.org/10.1038/ni0305-227

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