Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Deadly plague versus mild-mannered TLR4

Yersinia pestis evades lipopolysaccharide (LPS)-induced inflammation and establishes deadly infection mediated by myriad virulence factors. Virulence can be completely neutralized, however, if Y. pestis expresses a Toll-like receptor 4–stimulating LPS.

This is a preview of subscription content, access via your institution

Access options

Buy this article

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Y. pestis life cycle, inhibition of TLR4 activation by wild-type Y. pestis, and activation of TLR4 by genetically modified Y. pestis.

Kim Caesar

References

  1. Montminy, S.W. et al. Nat. Immunol. 7, 1066–1073 (2006).

    Article  CAS  Google Scholar 

  2. Cornelis, G.R. Nat. Rev. Mol. Cell. Biol. 3, 742–752 (2002).

    Article  CAS  Google Scholar 

  3. Marketon, M.M., DePaolo, R.W., DeBord, K.L., Jabri, B. & Schneewind, O. Science 309, 1739–1741 (2005).

    Article  CAS  Google Scholar 

  4. Viboud, G.I. & Bliska, J.B. Annu. Rev. Microbiol. 59, 69–89 (2005).

    Article  CAS  Google Scholar 

  5. Mukherjee, S. et al. Science 312, 1211–1214 (2006).

    Article  CAS  Google Scholar 

  6. Mueller, C.A. et al. Science 310, 674–676 (2005).

    Article  CAS  Google Scholar 

  7. Poltorak, A. et al. Science 282, 2085–2088 (1998).

    Article  CAS  Google Scholar 

  8. Akira, S., Uematsu, S. & Takeuchi, O. Cell 124, 783–801 (2006).

    Article  CAS  Google Scholar 

  9. Vogel, S.N., Awomoyi, A.A., Rallabhandi, P. & Medvedev, A.E. J. Endotoxin Res. 11, 333–339 (2005).

    Article  CAS  Google Scholar 

  10. Rebeil, R., Ernst, R.K., Gowen, B.B., Miller, S.I. & Hinnebusch, B.J. Mol. Microbiol. 52, 1363–1373 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dziarski, R. Deadly plague versus mild-mannered TLR4. Nat Immunol 7, 1017–1019 (2006). https://doi.org/10.1038/ni1006-1017

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/ni1006-1017

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing