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HIV-1 adaptation to NK-cell-mediated immune pressure

Nature Medicine volume 17, page 1059 (2011)Cite this article

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Alter, G. et al. Nature 476, 96–100.

The authors show that natural killer (NK) cells can mediate immune pressure on HIV-1 in vivo in humans. The virus can evolve to evade this immune mechanism by selecting for alternative sequence polymorphisms that favor binding to inhibitory killer-cell immunoglobulin-like receptors on NK cells.

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  1. Meera Swami
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Swami, M. HIV-1 adaptation to NK-cell-mediated immune pressure. Nat Med 17, 1059 (2011). https://doi.org/10.1038/nm.2481

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