The expression of antibodies to protect against an infectious disease can be achieved by the injection into the host of vectors carrying the gene to the relevant antibodies. Here the authors demonstrate the applicability of this technique to protection from HIV in a humanized mouse model, showing this to be a valid route to pursue in vaccine development for humans (pages 296–300).
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Marina Corral Spence
Change history
07 May 2014
In the version of this article initially published, there are two incorrect sentences in the text due to incorrect interpretation of the publication highlighted in this News and Views article. The sentence “The VRC-07 anti–HIV–1 neutralizing IgG in the mucosa seemed high enough to reduce experimental HIV-1 challenge rates among vector-immunized animals by 62.5%” should read “The VRC-07 anti–HIV–1 neutralizing IgG in the mucosa was high enough to reduce experimental HIV–1 challenge rates among vector-immunized animals completely; other less potent antibodies protected less completely.” Also, the sentence “Furthermore, there was detectable depletion of CD4+ T cells in the spleen and gut, indicating that systematic spread of HIV–1 still occurred in animals, despite the presence of neutralizing antibodies in the mucosa at the time of challenge” should not have been included. In addition, the word “spleen” should not have been included in Figure 1. The label “episomally replicating AAV” in the figure should have been “Episomal AAV vector.” The errors have been corrected in the HTML and PDF versions of the article.
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Corey, L., McElrath, M. One shot forward for HIV prevention. Nat Med 20, 241–242 (2014). https://doi.org/10.1038/nm.3503
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DOI: https://doi.org/10.1038/nm.3503
