A recent study suggests that exposure to the mold Aspergillus induces the production of antibodies that neutralize interferon-γ (IFN-γ), which increases the risk of mycobacterial disease.
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References
Bustamante, J., Boisson-Dupuis, S., Abel, L. & Casanova, J.L. Semin. Immunol. 26, 454–470 (2014).
Chi, C.Y. et al. Medicine 95, e3927 (2016).
Browne, S.K. et al. N. Engl. J. Med. 367, 725–734 (2012).
Lin, C.-H.C. Nat. Med. 22, 994–1001 (2016).
Ku, C.L., et al. J. Allergy Clin. Immunol. 137, 945–948.e8 (2016).
Holland, S.M. Microbes Infect. 2, 1579–1590 (2000).
Patel, S.Y. et al. J. Immunol. 175, 4769–4776 (2005).
Trapnell, B.C., Whitsett, J.A. & Nakata, K. N. Engl. J. Med. 349, 2527–2539 (2003).
Rosen, L.B. et al. J. Immunol. 190, 3959–3966 (2013).
Puel, A. et al. J. Exp. Med. 207, 291–297 (2010).
Walter, J.E. et al. J. Clin. Invest. 125, 4135–4148 (2015).
Acknowledgements
This work was supported in part by the Intramural Research Program of the National Institute of Allergy and Infectious Disease, NIH.
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Notarangelo, L., Holland, S. Friendly fire: anti-cytokine antibodies elicited by microbes. Nat Med 22, 973–975 (2016). https://doi.org/10.1038/nm.4175
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DOI: https://doi.org/10.1038/nm.4175
