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US AIDS chief altered report on nevirapine safety risks

Nature Medicine volume 11, page 3 (2005)Cite this article

The drug has been shown to decrease mother-to-baby HIV transmission by 50%, but can also promote drug-resistant forms of the virus, which can limit treatment options for the mothers at later times. It has also been linked to potentially fatal liver toxicity, as well as less serious side effects.

In 2002, five years after the NIH began studying the drug in Uganda, several reviews of the trial pointed to flawed research practices and underreporting of side effects. The research was halted while the NIH and outside auditors reviewed the project. Tramont reinitiated the study 15 months later, after reportedly rewriting a report that said safety data collected from the trial may be inaccurate.

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    Emily Singer

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  1. Emily Singer
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Health minister ignites row over drugs for HIV mothers

Concern at cheap AIDS drug fears

Deaths bring South African HIV drug trials to a premature halt

http://www.nature.com/nm/special_focus/hiv/

http://www.nature.com/news/specials/aids/archive.html

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Singer, E. US AIDS chief altered report on nevirapine safety risks. Nat Med 11, 3 (2005). https://doi.org/10.1038/nm0105-3b

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