A trial of a childhood vaccine against a common respiratory virus went terribly wrong in the early 1960s. Instead of protecting children, the vaccine exacerbated disease in response to infection. We now have a better understanding as to why (pages 34–41).
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Katie Ris-Vicari
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Varga, S. Fixing a failed vaccine. Nat Med 15, 21–22 (2009). https://doi.org/10.1038/nm0109-21
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DOI: https://doi.org/10.1038/nm0109-21
