Activation of the contact system on bacterial surfaces provides a mechanism by which this cascade of proteolytic enzymes contributes to septic shock and inflammation (pages 298–302).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Colman, R.W. & Schmaier, A.H. Contact system: A vascular biology modulator with anticoagulant, profibrinolytic, antiadhesive, and proinflammatory attributes. Blood 90, 3819–3843 (1997).
Silverberg, M., Dunn, K.T., Garen, L. & Kaplan, A.P. Autoactivation of human Hageman factor: Demonstration utilizing a synthetic substrate. J. Biol. Chem. 255, 7281–7286 (1980).
Herwald, H. et al. Activation of the contact phase system on bacterial surfaces-a clue to serious complications in infectious diseases. Nature Med. 4, 298–302 (1998).
Molla, A., Yamamoto, T., Akaike, T. & Miyoshi, L. Activation of Hageman factor and prekallikrein and generation of kinin by various microbial proteases. J. Biol. Chem. 264, 10589–10594 (1989).
Pixley, R.A. et al. The contact system contributes to hypotension but not disseminated intravascular coagulation in lethal bacteremia: In vivo use of a monoclonal anti-factor XII antibody to block contact activation in baboons. J. Gin. Invest. 91, 61–68 (1993).
Hirsch, E.F., Nakajima, T., Oshima, G., Erdos, E.G. & Herman, C.M. Kinin system responses in sepsis after trauma in man. J. Surg. Res. 17, 147–153 (1974).
Colman, R.W. et al. Binding of high molecular weight kininogen to human endothelial cells is mediated via a site within domains 2 and 3 of the urokinase receptor. J. Clin. Invest. 100, 1481–1487 (1997).
Bradford, H.N. et al. Human kininogens regulate thrombin binding to platelets through the glycoprotein Ib-IX-V complex. Blood 90, 1508–1515 (1997).
Gustafson, E.J. et al. High molecular weight kininogen inhibits fibrinogen binding to cytoadhesins of neutrophils and platelets. J. Cell. Biol. 109, 377–387 (1989).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Colman, R. The contact system: A proinflammatory pathway with antithrombotic activity. Nat Med 4, 277–278 (1998). https://doi.org/10.1038/nm0398-277
Issue date:
DOI: https://doi.org/10.1038/nm0398-277
This article is cited by
-
The many faces of the contact pathway and their role in thrombosis
Journal of Thrombosis and Thrombolysis (2011)
