Inflammatory signals strongly influence the generation of T-cell memory after infection or vaccination. Experimental manipulation of these signals shortens the interval of time between administration of a vaccine and a booster (pages 748–756).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout

Katie Ris
References
Badovinac, V.P., Messingham, K.A.N., Jabbari, A., Haring, J.S. & Harty, J.T. Nat. Med. 11, 748–756 (2005).
Seder, R.A. & Ahmed, R. Nat. Immunol. 4, 835–842 (2003).
Woodland, D.L. Trends Immunol. 25, 98–104 (2004).
Janeway, C.A., Jr. Cold Spring Harb. Symp. Quant. Biol. 54 Pt 1, 1–13 (1989).
Badovinac, V.P., Tvinnereim, A.R. & Harty, J.T. Science 290, 1354–1358 (2000).
Whitmire, J.K., Tan, J.T. & Whitton, J.L. J. Exp. Med. 201, 1053–1059 (2005).
Wong, P., Lara-Tejero, M., Ploss, A., Leiner, I. & Pamer, E.G. J. Immunol. 172, 7239–7245 (2004).
Haring, J.S., Corbin, G.A. & Harty, J.T. J. Immunol. 174, 6791–6802 (2005).
Dudani, R. et al. Infect. Immun. 70, 1957–1964 (2002).
Bonifaz, L.C. et al. J. Exp. Med. 199, 815–824 (2004).
Bevan, M.J. Nat. Rev. Immunol. 4, 595–602 (2004).
Yamazaki, S. et al. J. Exp. Med. 198, 235–247 (2003).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Woodland, D., Blackman, M. Vaccine development: baring the 'dirty little secret'. Nat Med 11, 715–716 (2005). https://doi.org/10.1038/nm0705-715
Issue date:
DOI: https://doi.org/10.1038/nm0705-715
This article is cited by
-
Vaccines for tumour prevention
Nature Reviews Cancer (2006)