Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Brain TNF: Damage limitation or damaged reputation?

Mice lacking TNF receptors show increased neuronal damage in response to excitotoxins or cerebral ischemia implying that TNF is neuroprotective (pages 788–794).

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Rothwell, N.J. & Hopkins, S.J. Cytokines and the nervous system II: Actions and mechanisms of action. Trends Neurosci. 18, 130–136 (1995).

    Article  CAS  Google Scholar 

  2. Bruce, A.J. et al. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nature Med. 2, 788–794 (1996).

    Article  CAS  Google Scholar 

  3. Wong, G.H. Protective roles of cytokines against radiation: Induction of mitochondrial Mn SOD. Biochem. Biophys. Acta 1271, 205–209 (1995).

    PubMed  Google Scholar 

  4. Cheng, B. & Mattson, M.P. Tumour necrosis factors protect neurons against excitotoxic/metabolic insults and promote maintenance of calcium homeostasis. Neuron 12, 139–153 (1994).

    Article  CAS  Google Scholar 

  5. Chao, C.C., Hu, S., Ehrlich, L. & Peterson, P.K. Interleukin-1 and tumour necrosis factor a synergistically mediate neurotoxicity: Involvement of nitric oxide and of NMDA receptors. Brain Behav. Immun. 9, 355–365 (1995).

    Article  CAS  Google Scholar 

  6. Meda, L. et al. Activation of microglial cells by beta-amyloid protein and interferon-gamma. Nature 374, 647–650 (1995).

    Article  CAS  Google Scholar 

  7. Chao, C., Hu, S. & Peterson, P.K. Modulation of human microglial superoxide production by cytokines. J. Leuk. Biol. 58, 65–70 (1995).

    Article  CAS  Google Scholar 

  8. Rothwell, N.J. & Strijbos, P.J.L.M. Cytokines in neurodegeneration and repair. Int. J. Dev. Neurosci. 13, 179–185 (1995).

    Article  CAS  Google Scholar 

  9. Vandanabeele, P., DePercq, W., Beyaert, R. & Fiers, W. Two tumour necrosis factor receptors: Structure and functions. Trends Biochem. Sci. 5, 392–399 (1995).

    Google Scholar 

  10. Mitcham, J.L. et al. T1/ST2 signaling establishes it as a member of an expanding interleukin-1 receptor family. J. Biol. Chem. 271, 5777–5783 (1996).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rothwell, N., Luheshi, G. Brain TNF: Damage limitation or damaged reputation?. Nat Med 2, 746–747 (1996). https://doi.org/10.1038/nm0796-746

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nm0796-746

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing