Insight into the molecular mechanism of rapamycin's immunosuppressive effects provides the basis for a novel approach to regulating therapeutic gene expression (pages 1028-1032).
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References
Rivera, V.M. et al. A humanized system for phar-macologic control of gene expression. Nature Med. 2, 1028–1032 (1996).
Schokett, P., Difilippantonio, M., Hellman, N. & Schatz, D.G. A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice. Proc.Natl. Acad. Sci. USA 92, 6522–6526 (1995).
Brown, M. et al. Lac repressor can regulate expression from a hybrid SV40 early promoter containing a lac operator in animal cells. Cell 49, 603–612 (1987).
Schreiber, S.L. Chemistry and biology of the immunophilins and their immunosuppressive ligands. Science 251, 283 (1991).
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Wilson, J. A pharmacologenic rheostat for gene therapy. Nat Med 2, 977–978 (1996). https://doi.org/10.1038/nm0996-977
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DOI: https://doi.org/10.1038/nm0996-977