Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Yayoi era mutation disrupts brain and muscle

Nature Medicine volume 4, pages 1002–1003 (1998)Cite this article

Abstract

Cloning of the fukutin gene reveals that an ancient retrotransposon insertion causes Fukuyama-type congenital muscular dystrophy, a disease with high prevalence among the Japanese.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Kobayashi, K. et al. An ancient retrotransposal insertion causes Fukuyama-type congenital muscular dystrophy. Nature 394, 388–392 (1998).

    Article  CAS  Google Scholar 

  2. Fukuyama, Y., Osawa, M. & Suzuki, H. Congenital progressive muscular dystrophy of the Fukuyama type--clinical, genetic and pathological considerations. Brain Dev. 3, 1–29 ( 1981).

    Article  CAS  Google Scholar 

  3. Kobayashi, K. et al. Founder-haplotype analysis in Fukuyama-type congenital muscular dystrophy (FCMD). Hum. Genet. In the press.

  4. Smit, A.F. The origin of interspersed repeats in the human genome. Curr. Opin. Genet. Dev. 6, 743–748 ( 1996).

    Article  CAS  Google Scholar 

  5. Kazazian, H.H. Mobile elements and disease. Curr. Opin. Genet. Dev. 8, 343–350 (1998).

    Article  CAS  Google Scholar 

  6. Brown, R.H. Dystrophin-associated proteins and the muscular dystrophies. Annu. Rev. Med. 48, 457–466 ( 1997).

    Article  CAS  Google Scholar 

  7. Voit, T. Congenital muscular dystrophies: 1997 update. Brain Dev. 20, 65–74 (1998).

    Article  CAS  Google Scholar 

  8. Pearlman, A.L., Faust, P.L., Hatten, M.E. & Brunstrom, J.E. New directions for neuronal migration. Curr. Opin. Neurobiol. 8, 45–54 (1998).

    Article  CAS  Google Scholar 

  9. D'Arcangelo, G. & Curran, T. Reeler: new tales on an old mutant mouse. BioEssays 20, 235–244 (1998).

    Article  CAS  Google Scholar 

  10. Tinsley, J.M. et al. Amelioration of the dystrophic phenotype of mdx mice using a truncated utrophin transgene. Nature 384, 349–353 (1996).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. St. Jude Children's Research Hospital Department of Developmental Neurobiology, Memphis, 38105, Tennesse, USA

    Derek E. Eberhart & Tom Curran

Authors
  1. Derek E. Eberhart
    View author publications

    Search author on:PubMed Google Scholar

  2. Tom Curran
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Eberhart, D., Curran, T. Yayoi era mutation disrupts brain and muscle. Nat Med 4, 1002–1003 (1998). https://doi.org/10.1038/1988

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/1988

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing