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From stem cells to germ cells and back again

Nature Medicine volume 14, pages 1188–1190 (2008)Cite this article

Producing germ cells in vitro would open important new avenues for regenerative medicine, and obtaining alternative sources of pluripotent stem cells is desirable. In this regard, Geijsen et al. have shown that it is possible to differentiate stem cells into cells similar to male gametes, whereas Guan et al. reported the ability to turn undifferentiated germ cells into pluripotent stem cells.

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Figure 1: In vitro differentiation of ES cells into gametes and back.

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Authors and Affiliations

  1. Marco Conti and Linda Giudice are in the Center for Reproductive Sciences and the Department of Obstetrics and Gynecology and Reproductive Sciences, University of California at San Francisco, 513 Parnassus Avenue, Health Sciences West 1656, Box 0556, San Francisco, California 94143, USA. contim@obgyn.ucsf.edu,

    Marco Conti & Linda Giudice

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  1. Marco Conti
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  2. Linda Giudice
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Conti, M., Giudice, L. From stem cells to germ cells and back again. Nat Med 14, 1188–1190 (2008). https://doi.org/10.1038/nm1108-1188

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