Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to the Editor
  • Published:

Reply to “The cystic fibrosis heterozygote advantage”

Nature Medicine volume 1, pages 1100–1101 (1995)Cite this article

Access through your institution
Buy or subscribe

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Schroeder, S.A., Gaughan, D.M. & Swift, M. Protection against bronchial asthma by CFTR εF508 mutation: A heterozygote advantage in cystic flbrosis. Nature Med. 1, 703–705 (1995).

    Article  CAS  Google Scholar 

  2. Mennie, M., Gilfillan, A. & Brock, D.J.H. Heterozygotes for the εF508 cystic fibrosis allele are not protected against bronchial asthma. Nature Med. 1, 978–979 (1995).

    Article  CAS  Google Scholar 

  3. Garenne, M., Ronsmans, C. & Campbell, H. The magnitude of mortality from acute respiratory infections in children under 5 years in developing countries. Wld Hlth Statist. Q. 45, 180–191 (1992).

    CAS  Google Scholar 

  4. Gergen, P.J. & Weiss, K.B. Epidemiology of asthma. in Asthma and Rhinitis (eds Busse, W.W. & Holgate, S.T.) (Blackwell Science, Oxford, 1995).

    Google Scholar 

  5. Newman-Taylor, A. Environmental determinants of asthma. Lancet 345, 296–299 (1995).

    Article  CAS  Google Scholar 

  6. Romagnani, S. Role of Th2 lymphocytes in the genesis of allergic disorders and mechanisms involved in their development. in Asthma: Physiology, Immunopharmacology and Treatment Fourth International Symposium (Academic Press, 1993).

    Google Scholar 

  7. Jorde, L.B. & Lathrop, G.M. A test of the heterozygote-advantage hypothesis in cystic fibrosis carriers. Am. J. hum. Genet. 42, 808–815 (1988).

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Korppi, M. et al. Bronchial asthma and hyperre-activity after early childhood bronchiolitis or pneumonia. An 8-year follow-up study. Arch. Pediatr. Adolesc. Med. 148, 1079–1084 (1194).

    Article  Google Scholar 

  9. Mennie, M.F. et al. Prenatal screening for cystic fibrosis. Lancet 340, 214–217 (1992).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, The Institute for the Genetic Analysis of Common Diseases, New York Medical College, 4 Skyline Drive, Hawthorne, New York, 10532, USA

    Michael Swift & Scott Schroeder

Authors
  1. Michael Swift
    View author publications

    Search author on:PubMed Google Scholar

  2. Scott Schroeder
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Swift, M., Schroeder, S. Reply to “The cystic fibrosis heterozygote advantage”. Nat Med 1, 1100–1101 (1995). https://doi.org/10.1038/nm1195-1100c

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nm1195-1100c

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing