Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Peptide vaccination against cancer?

Micrometastases in a murine lung carcinoma model have regressed or been prevented (pages 1179–1183).

This is a preview of subscription content, access via your institution

Access options

Buy this article

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Mandelboim, O. et al. Regression of established murine carcinoma metastases following vaccination with tumor associated antigen peptides. Nature Med. 1, 1179–1183 (1995).

    Article  CAS  Google Scholar 

  2. Boon, T., Certottini, J., van den Eynde, B., van der Bruggen, P. & Van Pel, A. Tumor antigens recognized by T lymphocytes. Annu. Rev. Immun. 12, 337–365 (1994).

    Article  CAS  Google Scholar 

  3. Nanda, N. & Sercarz, E. Induction of anti-self-immunity to cure cancer. Cell 82, 13–17 (1995).

    Article  CAS  Google Scholar 

  4. Moller, G. Tumor immunology. Immunol. Rev. 145, 5–250 (1995).

    Article  Google Scholar 

  5. Mandelboim, O. et al. CTL induction by a tumour associated antigen octapeptide derived from a murine lung carcinoma. Nature 369, 67–71 (1994).

    Article  CAS  Google Scholar 

  6. Cox, A. et al. Identification of a peptide recognized by five melanoma-specific human cytotoxic T Cell lines. Science 264, 716–719 (1994).

    Article  CAS  Google Scholar 

  7. Castelli, C. et al. Mass spectrometric identification of a naturally processed melanoma peptide recognized by CD8+ cytotoxic T lymphcytes. J. exp. Med. 181, 363–368 (1995).

    Article  CAS  Google Scholar 

  8. Van den Eynde, B. . et al. A new family of genes coding for an antigen recognized by autologus cytolytic T lymphocytes on a human melanoma. J. exp. Med. 182, 689–698 (1995).

    Article  CAS  Google Scholar 

  9. Wolfel, T. et al. Ap16-INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science 269, 1281–1284 (1995).

    Article  CAS  Google Scholar 

  10. Ressing, M. et al. Human CTL epitopes encoded by human papillomavirus type 16 E6 and E7 identified through in vivo and in vitro immunogenicity studies of HLA-A*0201-binding peptides. J. Immun. 154, 5934–5943 (1995).

    CAS  PubMed  Google Scholar 

  11. Krensky, A., Reiss, C., Mier, J., Strominger, J., Burakoff, S. Long-term human cytolytic T-Cell lines allospecific for HLA-DR6 antigen are OKT4+. Proc. natn. Acad. Sci. USA. 79, 2365–2369 (1982).

    Article  CAS  Google Scholar 

  12. Monach, P., Meredith, S., Siegel, C. & Schreiber, H. A unique tumor antigen produced by a single amino acid substitution. Immunity 2, 45–49 (1995).

    Article  CAS  Google Scholar 

  13. Melief, C. & Kast, M. T-Cell immunotherapy of tumors by adoptive transfer of cytotoxic T lymphocytes and by vaccination with minimal essential epitopes. Immunol. Rev. 146, 167–177 (1995).

    Article  Google Scholar 

  14. Feltkamp, M. et al. Cytotoxic T lymphocytes raised against a subdominant epitope offered as a synthetic peptide eradicate human papillomavirus type16-induced tumors. Eur. J. Immunol. 25, 2638–2642 (1995).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Strominger, J. Peptide vaccination against cancer?. Nat Med 1, 1140 (1995). https://doi.org/10.1038/nm1195-1140

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nm1195-1140

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing