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Retrovirus–mediated p53 gene therapy

Nature Medicine volume 2, page 1163 (1996)Cite this article

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References

  1. Roth, J.A. et al. Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer. Nature Med. 2, 985–991 (1996).

    Article  CAS  Google Scholar 

  2. Flaman, J.M. et al. A simple p53 functional assay for screening cell lines, blood, and tumors. Proc. Natl. Acad. Sci. USA 92, 3963–3967 (1995).

    Article  CAS  Google Scholar 

  3. Tada, M. et al. Clonality and stability of the p53 gene in human astrocytic tumor cells — quantitative analysis of p53 gene mutations by yeast functional assay. Int. J. Cancer 67, 447–450 (1996).

    Article  CAS  Google Scholar 

  4. Temin, H.M. Evolution of cancer genes as a mutation-driven process. Cancer Res. 48, 1697–1701 (1988).

    CAS  PubMed  Google Scholar 

  5. Flaman, J.M. et al. A rapid PCR fidelity assay. Nucleic Acids Res. 22, 3259–3260 (1994).

    Article  CAS  Google Scholar 

  6. Finlay, C.A., Hinds, P.W. & Levine, A.J. The p53 proto-oncogene can act as a suppressor of transformation. Cell 57, 1083–1093 (1989).

    Article  CAS  Google Scholar 

  7. Dittmer, D. et al. Gain of function mutations in p53 . Nature Genet. 4, 42–45 (1993).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Swiss Institute for Experimental Cancer Research (ISREC), 1066, Epalinges, Switzerland

    Anne Estreicher & Richard Iggo

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  1. Anne Estreicher
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  2. Richard Iggo
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Estreicher, A., Iggo, R. Retrovirus–mediated p53 gene therapy. Nat Med 2, 1163 (1996). https://doi.org/10.1038/nm1196-1163a

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