The identification of a new influenza virus protein PB1-F2, which localizes to mitochondria and causes cell death, may offer important insights into pathogenicity, as well as providing another example of how the virus can expand the coding capacity of its genome using overlapping reading frames. (pages 1306–1312)
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References
Wright, P.F. & Webster, R.G. Orthomyxoviruses. in Fields Virology, 4th ed. (eds. Knipe, D.M. & Howley, P.M.) 1533–1579 (Lippincott, Williams and Wilkins, Philadelphia, 2001).
Webster, R.G. Virology. A molecular whodunit. Science 293, 1773–1775 (2001).
Tyler, K.L. & Nathanson, N. Pathogenesis of viral infections. in Fields Virology, 4th ed. (eds. Knipe, D.M. & Howley, P.M.) 199–2431 (Lippincott, Williams and Wilkins, Philadelphia, 2001).
Steinhauer, D.A. Role of hemagglutinin cleavage for the pathogenicity of influenza virus. Virology 258, 1–20 (1999).
Hatta, M., Gao, P., Halfmann, P. & Kawaoka, Y. Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. Science 293, 1840–1842 (2001).
Garcia-Sastre, A. Inhibition of interferon-mediated antiviral responses by influenza A viruses and other negative-strand RNA viruses. Virology 279, 375–384 (2001).
Chen, W. et al. A novel influenza A virus mitochondrial protein that induces cell death. Nature Med. 1306–1312 (2001).
Lamb, R.A. The influenza virus RNA segments and their encoded proteins. in Genetics of Influenza Viruses (eds. Palese, P. & Kingsbury, D.W.) 26–69 (Springer, Vienna, 1983).
Schultz-Cherry, S., Dybdahl-Sissoko, N., Neumann, G., Kawaoka, Y. & Hinshaw, V.S. Influenza virus NS1 protein induces apoptosis in cultured cells. J. Virol. 75, 7875–7881 (2001).
Lamb, R.A. & Krug, R.M. Orthomyxoviridae: The viruses and their replication. in Fields Virology, 4th ed. (eds. Knipe, D.M. & Howley, P.M.) 1487–1531 (Lippincott, Williams and Wilkins, Philadelphia, 2001).
Lamb, R.A. & Kolakofsky, D. Paramyxoviridae: The viruses and their replication. in Fields Virology, 4th ed. (eds. Knipe, D.M. & Howley, P.M.) 1305–1340 (Lippincott, Williams and Wilkins, Philadelphia, 2001).
Paragas, J. et al. Influenza B and C virus NEP (NS2) proteins possess nuclear export activities. J. Virol. 75, 7375–7383 (2001).
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Lamb, R., Takeda, M. Death by influenza virus protein. Nat Med 7, 1286–1288 (2001). https://doi.org/10.1038/nm1201-1286
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DOI: https://doi.org/10.1038/nm1201-1286
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