Ouabain signaling through a plasma membrane can produce oscillations of intracellular calcium levels, resulting in translocation of the NF-κB transcription factor into the nucleus and gene activation. This is a previously unrecognized form of steroid action.
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Scheiner-Bobis, G., Schoner, W. A fresh facet for ouabain action. Nat Med 7, 1288–1289 (2001). https://doi.org/10.1038/nm1201-1288
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DOI: https://doi.org/10.1038/nm1201-1288
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